Dr David Turner BSc (Hons) PhD FHEA CBiol MRSB

Group Leader & Lecturer in Developmental and Stem Cell Biology Musculoskeletal & Ageing Science

Work email David.Turner@liverpool.ac.uk
Personal WebsiteThe Liverpool Development and Stem Cell Lab
ORCID0000-0002-3447-7662

Publications

Selected Publications

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids (Journal article - 2018)
Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids (Journal article - 2017)
Brachyury cooperates with Wnt/beta-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells (Journal article - 2014)
Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells (Journal article - 2014)
Gastruloids develop the three body axes in the absence of extraembryonic tissues and spatially localised signalling (Journal article - 2017)

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2023

Modifying gastruloids to dissect mechanisms of tissue-specific induction. (Journal article)

Turner, D. A., & Nichols, J. (2023). Modifying gastruloids to dissect mechanisms of tissue-specific induction.. Current opinion in genetics & development, 83, 102130. doi:10.1016/j.gde.2023.102130

DOI: 10.1016/j.gde.2023.102130

Novel 3D in vitro human placenta-on-a-chip model derived using human trophoblast stem cells differentiated towards syncytiotrophoblasts and extravillous trophoblasts to mimic both villi and implantation sides of the placenta. (Conference Paper)

Radziun, K., Sharp, A., Aye, I., Turner, D., Kadioglu, A., & Yang, M. (2023). Novel 3D in vitro human placenta-on-a-chip model derived using human trophoblast stem cells differentiated towards syncytiotrophoblasts and extravillous trophoblasts to mimic both villi and implantation sides of the placenta.. In Placenta Vol. 140 (pp. e27). Elsevier BV. doi:10.1016/j.placenta.2023.07.101

DOI: 10.1016/j.placenta.2023.07.101

NOVEL 3D IN VITRO HUMAN PLACENTA-ON-A-CHIP MODEL DERIVED USING HUMAN TROPHOBLAST STEM CELLS DIFFERENTIATED TOWARDS SYNCYTIOTROPHOBLASTS AND EXTRAVILLOUS TROPHOBLASTS TO MIMIC BOTH VILLI AND IMPLANTATION SIDES OF THE PLACENTA (Conference Paper)

Radziun, K., Sharp, A., Aye, I., Turner, D., Kadioglu, A., & Yang, M. (2023). NOVEL 3D IN VITRO HUMAN PLACENTA-ON-A-CHIP MODEL DERIVED USING HUMAN TROPHOBLAST STEM CELLS DIFFERENTIATED TOWARDS SYNCYTIOTROPHOBLASTS AND EXTRAVILLOUS TROPHOBLASTS TO MIMIC BOTH VILLI AND IMPLANTATION SIDES OF THE PLACENTA. In PLACENTA Vol. 140 (pp. E27-E28). Retrieved from https://www.webofscience.com/

Negative feedback on Retinoic Acid by Brachyury guides gastruloid symmetry-breaking (Preprint)

DOI: 10.1101/2023.06.02.543388

RNA binding protein HUR regulate osteoclast induction capacity of MG63 cells (Conference Paper)

Fu, S., Turner, D., & Tew, S. (2023). RNA binding protein HUR regulate osteoclast induction capacity of MG63 cells. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A5-A6). Retrieved from https://www.webofscience.com/

2021

Sculpting with stem cells: how models of embryo development take shape (Journal article)

Veenvliet, J. V., Lenne, P. -F., Turner, D. A., Nachman, I., & Trivedi, V. (2021). Sculpting with stem cells: how models of embryo development take shape. DEVELOPMENT, 148(24). doi:10.1242/dev.192914

DOI: 10.1242/dev.192914

Gastruloids: Embryonic Organoids from Mouse Embryonic Stem Cells to Study Patterning and Development in Early Mammalian Embryos (Journal article)

Anlas, K., Baillie-Benson, P., Arató, K., Turner, D., & Trivedi, V. (n.d.). Gastruloids: Embryonic Organoids from Mouse Embryonic Stem Cells to Study Patterning and Development in Early Mammalian Embryos. Methods in Molecular Biology, 2258, 131-147. doi:10.1007/978-1-0716-1174-6_10

DOI: 10.1007/978-1-0716-1174-6_10

2018

Generating Gastruloids from Mouse Embryonic Stem Cells (Journal article)

Beccari, L., Girgin, M., Turner, D. A., Baillie-Johnson, P., Cossy, A. -C., Beccari, L., . . . Martinez Arias, A. (n.d.). Generating Gastruloids from Mouse Embryonic Stem Cells. Protocol Exchange. doi:10.1038/protex.2018.094

DOI: 10.1038/protex.2018.094

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids (Journal article)

Beccari, L., Moris, N., Girgin, M., Turner, D. A., Baillie-Johnson, P., Cossy, A. -C., . . . Martinez Arias, A. (2018). Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids. Nature, 562(7726), 272-276. doi:10.1038/s41586-018-0578-0

DOI: 10.1038/s41586-018-0578-0

2017

Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids (Journal article)

Turner, D. A., Girgin, M., Alonso-Crisostomo, L., Trivedi, V., Baillie-Johnson, P., Glodowski, C. R., . . . Arias, A. M. (2017). Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids. DEVELOPMENT, 144(21), 3894-3906. doi:10.1242/dev.150391

DOI: 10.1242/dev.150391

From organoids to Gastruloids (Journal article)

Turner, D. A. (2017). From organoids to Gastruloids. Biologist, 64(5), 14-19. Retrieved from https://thebiologist.rsb.org.uk/

Gastruloids develop the three body axes in the absence of extraembryonic tissues and spatially localised signalling (Journal article)

Turner, D. A., Alonso-Crisostomo, L., Girgin, M., Baillie-Johnson, P., Glodowski, C. R., Hayward, P. C., . . . Martinez Arias, A. (2017). Gastruloids develop the three body axes in the absence of extraembryonic tissues and spatially localised signalling. doi:10.1101/104539

DOI: 10.1101/104539

2016

Interactions between Nodal and Wnt signalling Drive Robust Symmetry-Breaking and Axial Organisation inGastruloids(Embryonic Organoids) (Journal article)

Turner, D. A., Glodowski, C. R., Alonso-Crisostomo, L., Baillie-Johnson, P., Hayward, P. C., Collignon, J., . . . Martinez Arias, A. (2016). Interactions between Nodal and Wnt signalling Drive Robust Symmetry-Breaking and Axial Organisation inGastruloids(Embryonic Organoids). doi:10.1101/051722

DOI: 10.1101/051722

Organoids and the genetically encoded self-assembly of embryonic stem cells (Journal article)

Turner, D. A., Baillie-Johnson, P., & Arias, A. M. (2016). Organoids and the genetically encoded self-assembly of embryonic stem cells. BIOESSAYS, 38(2), 181-191. doi:10.1002/bies.201500111

DOI: 10.1002/bies.201500111

2015

Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour In Vitro (Journal article)

Baillie-Johnson, P., van den Brink, S. C., Balayo, T., Turner, D. A., & Martinez Arias, A. (n.d.). Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour In Vitro. Journal of Visualized Experiments, (105). doi:10.3791/53252-v

DOI: 10.3791/53252-v

Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour In Vitro. (Journal article)

Baillie-Johnson, P., van den Brink, S. C., Balayo, T., Turner, D. A., & Martinez Arias, A. (2015). Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour In Vitro.. Journal of visualized experiments : JoVE, (105). doi:10.3791/53252

DOI: 10.3791/53252

2014

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells (Journal article)

van den Brink, S. C., Baillie-Johnson, P., Balayo, T., Hadjantonakis, A. -K., Nowotschin, S., Turner, D. A., & Arias, A. M. (2014). Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells. DEVELOPMENT, 141(22), 4231-4242. doi:10.1242/dev.113001

DOI: 10.1242/dev.113001

Wnt/β-catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse embryonic stem cells (Journal article)

Turner, D. A., Hayward, P. C., Baillie-Johnson, P., Rue, P., Broome, R., Faunes, F., & Arias, A. M. (2014). Wnt/β-catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse embryonic stem cells. Development, 141(22), 4243-4253. doi:10.1242/dev.112979

DOI: 10.1242/dev.112979

Brachyury cooperates with Wnt/beta-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells (Journal article)

Turner, D. A., Rue, P., Mackenzie, J. P., Davies, E., & Arias, A. M. (2014). Brachyury cooperates with Wnt/beta-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells. BMC BIOLOGY, 12. doi:10.1186/s12915-014-0063-7

DOI: 10.1186/s12915-014-0063-7

An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells (Journal article)

Turner, D. A., Trott, J., Hayward, P., Rue, P., & Arias, A. M. (2014). An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells. BIOLOGY OPEN, 3(7), 614-626. doi:10.1242/bio.20148409

DOI: 10.1242/bio.20148409

Generation of Aggregates of Mouse ES Cells that Show Symmetry Breaking, Polarisation and Emergent Collective Behaviour in vitro. (Preprint)

DOI: 10.1101/005215

Brachyury cooperates with Wnt/β-Catenin signalling to elicit Primitive Streak like behaviour in differentiating mouse ES cells. (Preprint)

DOI: 10.1101/003871

2013

An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells (Preprint)

DOI: 10.1101/000653

2010

An Investigation into the Dynamics of NF-kappaB Following Physiological Levels of Cytokine Stimulation in Single Living Cells (Thesis / Dissertation)

Turner, D. (2010, September). An Investigation into the Dynamics of NF-kappaB Following Physiological Levels of Cytokine Stimulation in Single Living Cells.

Physiological levels of TNFα stimulation induce stochastic dynamics of NF-κB responses in single living cells (Journal article)

Turner, D. A., Paszek, P., Woodcock, D. J., Nelson, D. E., Horton, C. A., Wang, Y., . . . Harper, C. V. (2010). Physiological levels of TNFα stimulation induce stochastic dynamics of NF-κB responses in single living cells. JOURNAL OF CELL SCIENCE, 123(16), 2834-2843. doi:10.1242/jcs.069641

DOI: 10.1242/jcs.069641

2009

Information management for high content live cell imaging (Journal article)

Jameson, D., Turner, D. A., Ankers, J., Kennedy, S., Ryan, S., Swainston, N., . . . Paton, N. W. (2009). Information management for high content live cell imaging. BMC BIOINFORMATICS, 10. doi:10.1186/1471-2105-10-226

DOI: 10.1186/1471-2105-10-226