Molecular Biology and Molecular Mechanisms of Disease


‌ ‌Luminita Paraoan


Professor Luminita Paraoan, MSc (Biochem), PhD

Group leader Ocular Molecular biology and Mechanisms of Disease

  • Graduated from University of Bucharest (Biochemistry) in 1990; PhD in Genetics and Microbiology from The Romanian Academy of Sciences in 1996 and a further PhD in Biochemistry from The University of Liverpool in 1998.
  • Fulbright research Scholar at The Johns Hopkins University, Baltimore, USA, 1992-1993 Wellcome Trust Prize studentship in The Department of Biochemistry, University of Liverpool, UK.
  • Wellcome Trust Prize Fellow at The University of Liverpool, UK, 1998-2000
  • Appointed Lecturer in 2003 in the Department of Medicine, Senior Lecturer in 2006 in the School of Clinical Science, Faculty of Medicine and Reader in the Department of Eye and Vision Science, Faculty of Health and Life Sciences, University of Liverpool.
  • Since 2016 Luminita is Professor of Ocular Molecular and Cellular Biology in the Faculty of Health and Life Sciences, University of Liverpool.
 Umar Sharif


Dr Umar Sharif (Post-doctoral researcher)

Role of proteolysis in retinal pigmented epithelium in normal physiology and diseases. Study of proteolytic events that involve a network of proteases that mediate human retinal pigmented epithelial cell physiology and its interaction with its surrounding environment including photoreceptors and choroidal blood supply.


Dr Emil Carlsson (Post-doctoral researcher)

Graduated from KTH Royal Institute of Technology (MSc in Biotechnology Engineering) in 2008. PhD in Molecular Biosciences from Imperial College London and the National University of Singapore (joint degree) in 2016. Current project involves gene editing of risk factor for age-related macular degeneration to study the effect of modulation of proteolytic control in retinal pigment epithelial cells. 



Dr Samantha McDonnell (Post-doctoral researcher)

Investigating protein-protein interactions involved in PERP-mediated apoptosis.



Nur Musfirah Mahmud (PhD student)

Graduated with Bsc (Hons.) in Biomolecular Science from Universiti Teknologi MARA (UiTM) Malaysia in 2013. Currently working on "Investigation of the effects of ageing and oxidative stress response in retinal cells", in collaboration with University of Malaya, Kuala Lumpur.


Kaiyue EVS


Kaiyue Teng (PhD student)

Role of posttranslational modifications in regulation of PERP function and related cell death/signalling mechanisms


Neil Saptarshi (PhD Student)

Investigating Epigenetic Changes in Age-related Macular Degeneration: From Differentially Methylated Locus to Functional Consequence

My work in Professor Paraon’s group focuses on identifying, validating and initiating mechanistic studies of differentially methylated genes in RPE/Choroid-derived gDNA from dry-AMD patients. Validated and biologically relevant genes will be thoroughly tested and their contribution to disease pathogenesis determined



Lewis Kelly (MRes student)

I’m Lewis and I’m a MRes in Advanced Biological Sciences student. My work focuses on Protein-protein interactions of Cystatin C in the RPE. I will be investigating the variant and wild type forms of the protein, and attempting to relate some specific interactions to the epidemiology of AMD. 

Sean EVS

Sean Duffy (MPhil Student)

Epigenetic changes in age-related macular degeneration: Functional investigation of a novel validated target involved in transcription-controlled DNA repair


Owain Roberts (Post-doctoral researcher)

Studying crosstalk between signalling pathways modulating cell fate








































































































































































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