Molecular Biology and Molecular Mechanisms of Disease

Mechanisms of Disease in Age-related Macular Degeneration

Research is focused on two major scientific directions:

  1. Regulation of proteolysis and intracellular trafficking
  2. Cell signalling and programmed cell death (apoptosis) regulatory networks

There is a strong track record with close collaborative links on molecular/cellular and systems biology with groups in the Institute of Integrative Biology, as well as national (Manchester, Leeds, Wolverhampton) and international (USA, China, Spain, Singapore) collaborations.

Image: Live RPE cell expressing transfected cystatin C-GFP fusion protein

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Research impact press release December 2016

 

Mechanisms of Disease in Glaucoma

We are studying disease mechanisms in glaucoma associated with the trabecular meshwork (TM). These include the identification of cross linked actin networks (CLANs) in the TM and optic nerve and investigating the role of Thrombospondin 1 and 2 with a potential of developing new treatment strategies for glaucoma.