Molecular Biology and Molecular Mechanisms of Disease

Selected Publications

 Butler JM, Hall N, Narendran N, Yang YC, Paraoan L. Identification of candidate protective variants for common diseases and evaluation of their protective potential.

BMC Genomics. 2017 18(1):575. doi: 10.1186/s12864-017-3964-3. 

View abstract on Pubmed 

 

Awais, Spiller, White, Paraoan. p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma. Br J Cancer. 2016 Sep 1. PMID: 27584665. View Abstract on PubMed

Sant'Anna R, Navarro S, Ventura S, Paraoan L, Foguel D. Amyloid properties of the leader peptide of variant B cystatin C: implications for Alzheimer and Macular Degeneration. FEBS Lett. 2016 Feb 10. PMID: 26865059 View abstract on PubMed

Butler JM, Sharif U, Ali M, McKibbin M, Thompson JP, Gale R, Yang YC, Inglehearn C, Paraoan L. A missense variant in CST3 exerts a recessive effect on susceptibility to age-related macular degeneration resembling its association with Alzheimer's disease. Hum Genet. 2015 Apr 19. PMID: 25893795 View abstract on Pubmed

Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters K, Paraoan L, Casanova JE, Boll EJ, McCormick BA. PERP, a Host Tetraspanning Membrane Protein, is Required for Salmonella-Induced Inflammation. Cell Microbiol. 2014 Dec 9. PMID: 25486861 View abstract on Pubmed

Soriano-Romaní L, García-Posadas L, López-García A, Paraoan L, Diebold Y. Thrombospondin-1 induces differential response in human corneal and conjunctival epithelial cells lines under in vitro inflammatory and apoptotic conditions. Exp Eye Res. 2015 May;134:1-14. doi: 10.1016/j.exer.2015.03.004 View Abstract on Pubmed

Kay P, Yang YC, Hiscott P, Gray D, Maminishkis A, Paraoan L. Age-related changes of cystatin C expression and polarized secretion by retinal pigment epithelium: potential age-related macular degeneration links. Invest Ophthalmol Vis Sci. 2014 Feb 14. PMID: 24458156 View abstract on Pubmed

Kay P, Yang YC, Paraoan L. Directional protein secretion by the retinal pigment epithelium: roles in retinal health and the development of age-related macular degeneration. J Cell Mol Med. 2013 May 11. PMID: 23663427 View abstract on Pubmed

Davies L, Spiller D, White M R H, Grierson I, Paraoan L. PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. Cell Death and Disease 2011 Mar 31; 2:e136. PMID: 21451571 View abstract on Pubmed

O'Reilly S, Pollock N, Currie L, Paraoan L, Clark AF, Grierson I. Inducers of cross-linked actin networks in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 Sep 21;52(10):7316-24. doi: 10.1167/iovs.10-6692 View abstract on Pubmed

Paraoan L, Hiscott P, Gosden C, Grierson I. Cystatin C in macular and neuronal degenerations: Implications for mechanism(s) of Age-related Macular Degeneration. Vision Res. 2010 mar 31;50(7):737-742. PMID: 19917302 View abstract on Pubmed

Davies L, Gray D, Spiller D, White MRH, Damato B, Grierson I, Paraoan L. P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma. J Cell Mol Med. 2009 13;8B:1995-2007. PMID: 19040420 View abstract on Pubmed

Paraoan L, Gray D, Hiscott P, Garcia-Fianana M, Lane B, Damato B, Grierson I. Cathepsin S and its inhibitor Cystatin C: imbalance in uveal melanoma. Frontiers in Bioscience. 2009 Jan 1;14:2504-2513. PMID: 19273215 View abstract on Pubmed

Paraoan L, Gray D, Hiscott P, Ebrahimi B, Damato B, Grierson I. Expression of p53-induced apoptosis effector PERP in primary uveal melanomas: downregulation is associated with aggressive type. Exp Eye Res. 2006 Oct;83(4):911-9. PMID: 16784742 View Abstract on PubMed

Paraoan L, Grierson I. Focus on molecules: Cystatin C. Exp Eye Res. 2007 Jun;84(6):1019-20. PMID: 16626703 View Abstract on PubMed

Ratnayaka A, Paraoan L, Spiller DG, Hiscott P, Nelson G, White MR, Grierson I. A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: An additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility. Exp Eye Res. 2007 Jun;84(6):1135-9. PMID: 16635487 View Abstract on PubMed

Paraoan L, Grierson I, Maden BE. Fate of cystatin C lacking the leader sequence in RPE cells. Exp Eye Res. 2003 Jun;76(6):753-6. PMID: 12742358 View Abstract on PubMed

Paraoan L, Grierson I, Maden BE. Analysis of expressed sequence tags of retinal pigment epithelium: cystatin C is an abundant transcript. Int J Biochem Cell Biol. 2000 Apr;32(4):417-26. PMID: 10762067 View Abstract on PubMed

O'Reilly S, Pollock N, Currie L, Paraoan L, Clark AF, Grierson I. Inducers of cross-linked actin networks in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 Sep 21;52(10):7316-24. PMID: 21849423 View Abstract on PubMed

Wade NC, Grierson I, O'Reilly S, Hoare MJ, Cracknell KP, Paraoan L, Brotchie D, Clark AF. Cross-linked actin networks (CLANs) in bovine trabecular meshwork cells. Exp Eye Res. 2009;89(5):648-659. PMID: 19540832 View abstract on Pubmed

Cryan LM, Paraoan L, Hiscott P, Damato B, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, O'Brien C. Expression of COX-2 and prognostic outcome in uveal melanoma. Curr Eye Res. 2008 Mar 3;33:117-184. PMID: 18293189 View Abstract on Pubmed

Ratnayaka A, Paraoan L, Nelson G, Spiller DG, White MR, Hiscott P. Trafficking of osteonectin by retinal pigment epithelial cells: evidence for basolateral secretion. Int J Biochem Cell Biol. 2007;39(1):85-92. PMID: 17035068 View Abstract on PubMed

Hiscott P, Paraoan L, Choudhary A, Ordonez JL, Al-Khaier A, Armstrong DJ. Thrombospondin 1, thrombospondin 2 and the eye. Prog Retin Eye Res. 2006 Jan;25(1):1-18. PMID: 15996506 View Abstract on PubMed

Ordonez JL, Paraoan L, Hiscott P, Gray D, Garcia-Finana M, Grierson I, Damato B. Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma. Melanoma Res. 2005 Dec;15(6):495-502. PMID: 16314734 View Abstract on PubMed

Paraoan L, Ratnayaka A, Spiller DG, Hiscott P, White MR, Grierson I. Unexpected intracellular localization of the AMD-associated cystatin C variant. Traffic. 2004 Nov;5(11):152-65. PMID: 15479453 View Abstract on PubMed

Hiscott P, Hagan S, Heathcote L, Sheridan CM, Groenewald CP, Grierson I, Wong D, Paraoan L. Pathobiology of epiretinal and subretinal membranes: Possible roles for the matricellular proteins thrombospondin 1 and osteonectin (SPARC). Eye. 2002 Jul;16(4):393-403. PMID: 12101446 View Abstract on PubMed

Paraoan L, White MR, Spiller DG, Grierson I, Maden BE. Precursor cystatin C in cultured retinal pigment epithelial cells: evidence for processing through the secretory pathway. Mol Membr Biol. 2001 Jul-Sep;18(3):229-36. PMID: 11681790 View Abstract on PubMed