Molecular Biology and Mechanisms of Eye Disease

About our research

Our studies investigate the molecular mechanisms underpinning the functioning of ocular cells in health and disease.

An important part of our experimental strategy is to apply quantitative approaches to molecular cell biology and to combine advanced technologies in order to integrate biochemical, genetic and cellular understanding of specialised cell behaviour.

 Our research covers a number of major areas, including:

•Mechanisms of tissue homeostasis

•Age-related changes

•Checkpoint signalling and protein modification

•Response to cellular stresses

•Basement membrane structure and function

•Regulation of tissue behaviour by cellular microenvironments

•Biology of ocular stem cells

 Gaining a better understanding of these processes has important implications for ocular health and major eye diseases, including age-related macular degeneration, proliferative vitreoretinopathy, diabetic retinopathy, glaucoma and congenital disorders. The main purpose of unravelling the fundamental mechanisms of these diseases is to underpin translation into effective novel therapies.